Solubility and Thermodynamic Behavior of Naringenin in Water + Methanol Mixed Solvent Systems at Temperatures between 288.15 and 328.15K - Adel Noubigh - Carthage University

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Naringin (C27H32O14) with the chemical name 4′,5,7-trihydroxyflavanone-7-rhamnoglucoside, a flavanone glycoside that is frequently found in many citrus fruits especially grapefruit and lemon, such that it is responsible for the fruit's bitter taste. It has been reported that naringin can show biological effects like antioxidant, anti-inflammatory, anticancer (breast cancer), anti-allergic, anti-diabetic, anti-angiogenesis and cholesterol-lowering activities. As a plant flavonoid, naringin, has attracted significant scientific and public interest in recent years due to its versatile health-promoting effects. However, due to very poor solubility of naringin in water at room temperature, its bioavailability is low and this hinders further studies on its pharmacological applications