Zika virus infection is a new problematic arbovirus infection. The infection is a dengue like illness but can result in unwanted neurological complication and abnormal child born to infected mother. The infection occurs worldwide at present and it is still the global public health issue. To manage this infection, there is still no specific antiviral drug. Searching for new effective drug is widely performed. For prevention of the disease, the prevention of mosquito bite and safe sex is the main recommendation. As a new infection, the expected most effective preventive measure against Zika virus infection is the vaccination . Nevertheless, there is still no specific vaccine against Zika virus at present.