A note on Atherosclerosis
Atherosclerosis is a disease of blood vessels. In this condition, the innermost layer of the blood vessels (endothelium) is constricted by the deposition of fat, calcium and cellular debris. Atherosclerosis leads to the narrowing of the artery, which in turn reduces the flow of blood passing through it. The reduced blood flow results in a depletion of the amount of oxygen and nutrients reaching the affected part of the body.
Atherosclerosis is a progressive disease, which may either start in childhood or late adulthood. The exact cause of atherosclerosis is still unknown; however, plaque formation begins when there is damage to the endothelium of the artery. Some of the most common factors which are more likely to cause this damage are:
- Elevated cholesterol or triglyceride levels in the body
- High blood pressure
- Cigarette smoking
Other risk factors include:
- Diabetes mellitus
- Obesity
- Lack of exercise
- Sex (men are more prone)
- Family history of increased cholesterol
Early atherosclerosis does not present any symptoms. Symptoms may appear once the artery starts to become narrower. Symptoms may occur depending on the arteries that are affected. The various symptoms are:
- Chest pain
- Weakness
- Vision problems
- Speech problems
- Headache
- Pain in legs or feet
- Difficulty walking
Early diagnosis of atherosclerosis is important to prevent further complications. The physician evaluates the medical history and looks for the symptoms to diagnose atherosclerosis. Tests depend on the arteries that are affected. The various tests which help in diagnosing atherosclerosis are:
- Electrocardiogram
- Angiography
- Cardiac catheterization
- Ultrasonography examination
- Magnetic resonance imaging (MRI)
- Scintigraphy
- Doppler (especially lower limbs)
The treatment approach of atherosclerosis involves:
- Controlling risk factors
- Controlling blood pressure, blood sugar levels and cholesterol levels
- Smoking cessation
Medications which are effective in lowering cholesterol levels include:
- Statins
- Fibrates
- Bile acid sequestrates
Antiplatelet medications can be used to prevent blood from clotting or clogging arteries. Antihypertensive medications such as diuretics or angiotensin-converting enzyme inhibitors (ACEI) may be used to control blood pressure.
Lifestyles changes help treat as well as prevent atherosclerosis. The lifestyle changes that can be helpful include:
- Eating a healthy diet that is free of saturated fats and cholesterol
- Avoiding fried and fatty foods
- Consuming fish twice a week
- Exercising daily for at least three to four hours
- Quitting tobacco use
- Stress management
- Weight loss
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John Mathews
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Current Trends in Cardiology